Abstract
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology
-
Bacillus anthracis / drug effects
-
Bacillus anthracis / enzymology*
-
Crystallography, X-Ray
-
Drug Design
-
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / antagonists & inhibitors*
-
Microbial Sensitivity Tests
-
Models, Molecular
-
Molecular Structure
-
Molecular Weight
-
Pyridones / chemical synthesis*
-
Pyridones / chemistry
-
Pyridones / pharmacology
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Pyridones
-
2-hydroxypyridine
-
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)